MSP4BIO is a three-year EU-funded project (Aug 2022 – July 2025) aiming to develop an integrated flexible socio-ecological management system to deal with a rapidly changing environment for coastal, offshore and deep-sea ecosystems. By validating this system at six test sites in five European sea basins, MSP4BIO will enhance approaches, methods and tools to increase scientific knowledge. Marine biodiversity scientists as well as planners and marine protected areas managers will benefit from this work, which will also support policy processes and decisions. The aim is to support the implementation of the EU Biodiversity Strategy, the Convention on Biological Diversity and the EU Green Deal. MSP4BIO aims to protect and recover ecosystems thanks to knowledge-based marine spatial planning.